diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index f5a6f9ab90f..a513eda56b7 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -501,11 +501,11 @@ jobs:
             timeout-minutes: 120
             file-env: './ci/test/00_setup_env_native_previous_releases.sh'
 
-          - name: 'CentOS, depends, gui'
-            cirrus-runner: 'ghcr.io/cirruslabs/ubuntu-runner-amd64:24.04-lg'
+          - name: 'Alpine (musl), depends, gui'
+            cirrus-runner: 'ghcr.io/cirruslabs/ubuntu-runner-amd64:24.04-md'
             fallback-runner: 'ubuntu-24.04'
             timeout-minutes: 120
-            file-env: './ci/test/00_setup_env_native_centos.sh'
+            file-env: './ci/test/00_setup_env_native_alpine_musl.sh'
 
           - name: 'tidy'
             cirrus-runner: 'ghcr.io/cirruslabs/ubuntu-runner-amd64:24.04-md'
diff --git a/ci/test/00_setup_env_native_centos.sh b/ci/test/00_setup_env_native_alpine_musl.sh
similarity index 57%
rename from ci/test/00_setup_env_native_centos.sh
rename to ci/test/00_setup_env_native_alpine_musl.sh
index 998ddaf45f8..094709ff828 100755
--- a/ci/test/00_setup_env_native_centos.sh
+++ b/ci/test/00_setup_env_native_alpine_musl.sh
@@ -6,10 +6,10 @@
 
 export LC_ALL=C.UTF-8
 
-export CONTAINER_NAME=ci_native_centos
-export CI_IMAGE_NAME_TAG="quay.io/centos/centos:stream10"
-export CI_BASE_PACKAGES="gcc-c++ glibc-devel libstdc++-devel ccache make ninja-build git python3 python3-pip which patch xz procps-ng rsync coreutils bison e2fsprogs cmake dash"
-export PIP_PACKAGES="pyzmq pycapnp"
+export CONTAINER_NAME=ci_native_alpine_musl
+export CI_IMAGE_NAME_TAG="mirror.gcr.io/alpine:3.22"
+export CI_BASE_PACKAGES="build-base musl-dev pkgconf curl ccache make ninja git python3 py3-pip which patch xz procps rsync util-linux bison e2fsprogs cmake dash linux-headers"
+export PIP_PACKAGES="--break-system-packages pyzmq pycapnp"
 export DEP_OPTS="DEBUG=1"
 export GOAL="install"
 export BITCOIN_CONFIG="\
diff --git a/ci/test/01_base_install.sh b/ci/test/01_base_install.sh
index ce460987901..144b9ab253f 100755
--- a/ci/test/01_base_install.sh
+++ b/ci/test/01_base_install.sh
@@ -32,16 +32,17 @@ if [ -n "${APT_LLVM_V}" ]; then
   )
 fi
 
-if [[ $CI_IMAGE_NAME_TAG == *centos* ]]; then
-  bash -c "dnf -y install epel-release"
-  # The ninja-build package is available in the CRB repository.
-  bash -c "dnf -y --allowerasing --enablerepo crb install $CI_BASE_PACKAGES $PACKAGES"
+if [[ $CI_IMAGE_NAME_TAG == *alpine* ]]; then
+  ${CI_RETRY_EXE} apk update
+  # shellcheck disable=SC2086
+  ${CI_RETRY_EXE} apk add --no-cache $CI_BASE_PACKAGES $PACKAGES
 elif [ "$CI_OS_NAME" != "macos" ]; then
   if [[ -n "${APPEND_APT_SOURCES_LIST}" ]]; then
     echo "${APPEND_APT_SOURCES_LIST}" >> /etc/apt/sources.list
   fi
   ${CI_RETRY_EXE} apt-get update
-  ${CI_RETRY_EXE} bash -c "apt-get install --no-install-recommends --no-upgrade -y $PACKAGES $CI_BASE_PACKAGES"
+  # shellcheck disable=SC2086
+  ${CI_RETRY_EXE} apt-get install --no-install-recommends --no-upgrade -y $PACKAGES $CI_BASE_PACKAGES
 fi
 
 if [ -n "${APT_LLVM_V}" ]; then
diff --git a/ci/test/03_test_script.sh b/ci/test/03_test_script.sh
index cee09cdebd9..888ff0319c1 100755
--- a/ci/test/03_test_script.sh
+++ b/ci/test/03_test_script.sh
@@ -99,8 +99,8 @@ else
 fi
 
 if [ -z "$NO_DEPENDS" ]; then
-  if [[ $CI_IMAGE_NAME_TAG == *centos* ]]; then
-    SHELL_OPTS="CONFIG_SHELL=/bin/dash"
+  if [[ $CI_IMAGE_NAME_TAG == *alpine* ]]; then
+    SHELL_OPTS="CONFIG_SHELL=/usr/bin/dash"
   else
     SHELL_OPTS="CONFIG_SHELL="
   fi
diff --git a/ci/test_imagefile b/ci/test_imagefile
index f9cf3187a25..a0e1714ed5f 100644
--- a/ci/test_imagefile
+++ b/ci/test_imagefile
@@ -17,4 +17,7 @@ ENV BASE_ROOT_DIR=${BASE_ROOT_DIR}
 COPY ./ci/retry/retry /usr/bin/retry
 COPY ./ci/test/00_setup_env.sh ./${FILE_ENV} ./ci/test/01_base_install.sh /ci_container_base/ci/test/
 
+# Bash is required, so install it when missing
+RUN sh -c "bash -c 'true' || ( apk update && apk add --no-cache bash )"
+
 RUN ["bash", "-c", "cd /ci_container_base/ && set -o errexit && source ./ci/test/00_setup_env.sh && ./ci/test/01_base_install.sh"]